Genetic associations with micronutrient levels identified in immune and gastrointestinal networks
| Autor: | Jim Kaput, Lisa Pence, Beverly McCabe-Sellers, Jerome Turner, Anna J. Williams, Richard D. Beger, Corrado Priami, Jacqueline Pontes Monteiro, Beatrice Shelby, Catherine M. Champagne, Margaret L. Bogle, Baitang Ning, Candee H. Teitel, Melissa J. Morine, Carolyn Wise |
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| Rok vydání: | 2014 |
| Předmět: |
Vitamin
Endocrinology Diabetes and Metabolism medicine.medical_treatment data analysis Clinical nutrition Biology Bioinformatics chemistry.chemical_compound computational biology nutrigenomics Genetics medicine Genetic association chemistry.chemical_classification Community-based participatory research Vitamin E Genetic analysis Retinol bioinformatics Micronutrient Blood proteins GENÉTICA chemistry Network analysis Essential nutrient nutrigenomics bioinformatics computational biology data analysis Systems nutrition Research Paper |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Genes & Nutrition |
| Popis: | The discovery of vitamins and clarification of their role in preventing frank essential nutrient deficiencies occurred in the early 1900s. Much vitamin research has understandably focused on public health and the effects of single nutrients to alleviate acute conditions. The physiological processes for maintaining health, however, are complex systems that depend upon interactions between multiple nutrients, environmental factors, and genetic makeup. To analyze the relationship between these factors and nutritional health, data were obtained from an observational, community-based participatory research program of children and teens (age 6–14) enrolled in a summer day camp in the Delta region of Arkansas. Assessments of erythrocyte S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), plasma homocysteine (Hcy) and 6 organic micronutrients (retinol, 25-hydroxy vitamin D3, pyridoxal, thiamin, riboflavin, and vitamin E), and 1,129 plasma proteins were performed at 3 time points in each of 2 years. Genetic makeup was analyzed with 1 M SNP genotyping arrays, and nutrient status was assessed with 24-h dietary intake questionnaires. A pattern of metabolites (met_PC1) that included the ratio of erythrocyte SAM/SAH, Hcy, and 5 vitamins were identified by principal component analysis. Met_PC1 levels were significantly associated with (1) single-nucleotide polymorphisms, (2) levels of plasma proteins, and (3) multilocus genotypes coding for gastrointestinal and immune functions, as identified in a global network of metabolic/protein–protein interactions. Subsequent mining of data from curated pathway, network, and genome-wide association studies identified genetic and functional relationships that may be explained by gene–nutrient interactions. The systems nutrition strategy described here has thus associated a multivariate metabolite pattern in blood with genes involved in immune and gastrointestinal functions. Electronic supplementary material The online version of this article (doi:10.1007/s12263-014-0408-4) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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