Treatment of children with central precocious puberty by a slow-release gonadotropin-releasing hormone agonist
| Autor: | R J Odink, Wolfgang G. Sippell, E. A. van der Velde, Stenvert L. S. Drop, Wilma Oostdijk, Carl-Joachim Partsch, H. Schultheiss, F Lorenzen, R. Hümmelink |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Puberty Precocious Injections Intramuscular Gonadotropin-Releasing Hormone Menstruations Follicle-stimulating hormone chemistry.chemical_compound Internal medicine Gonadotropin-releasing hormone agonist medicine Humans Precocious puberty Child Breast development Triptorelin Pamoate Dehydroepiandrosterone Sulfate business.industry Cyproterone acetate Dehydroepiandrosterone Luteinizing Hormone medicine.disease Body Height Endocrinology Gonadarche chemistry Child Preschool Delayed-Action Preparations Pediatrics Perinatology and Child Health Female Follicle Stimulating Hormone business Luteinizing hormone |
| Zdroj: | European Journal of Pediatrics. 149:308-313 |
| ISSN: | 1432-1076 0340-6199 |
| Popis: | A total of 82 patients (74 girls, 8 boys) are presently participating in an international multicentre trial for treatment of central precocious puberty (CPP) with a slow release gonadotropin-releasing hormone (GnRH) agonist depot preparation: Decapeptyl-Depot (DD). Of these patients, 53 (3 boys) were previously untreated (group 1) and 29 (5 boys) have been treated before with either a short-acting GnRH analogue or cyproterone acetate (group 2). Fifty-one patients (44 girls, 7 boys) were treated with DD for 12 months or more. Basal plasma luteinizing hormone (LH) levels decreased in both groups after 1 year of therapy. The LH response to intravenous GnRH was reduced in both groups. Basal plasma follicle stimulating hormone (FSH) levels decreased in both groups. Stimulated FSH levels were reduced in both groups after 1 year of DD treatment. Plasma oestradiol levels in the girls decreased to prepubertal levels in both groups. In all patients the clinical signs of precocious gonadarche such as breast development and menstruations (girls) and an increased testis volume (boys), did not further progress and sometimes regressed in several patients. Growth velocity decreased in the girls of group 1 from 9.0±0.72cm/year (mean±SEM) in the last half-year before treatment to 6.3±0.50 in the first half-year of treatment (P |
| Databáze: | OpenAIRE |
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