Effects of administration of monoclonal antibodies (anti-CD4 or anti-CD8) on the development of autoimmune diseases in (NZW x BXSB)F1 mice
| Autor: | Minori Koshiji, Hisae Genba, Muneo Inaba, Yasushi Adachi, Kikuya Sugiura, Shinichiro Mori, Yasuo Amoh, Tetsuro Kamiya, Susumu Ikehara, Akira Sugihara |
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| Rok vydání: | 1998 |
| Předmět: |
CD4-Positive T-Lymphocytes
medicine.drug_class medicine.medical_treatment Immunology Kidney Glomerulus Lupus nephritis Monoclonal antibody Autoimmune Diseases Interferon-gamma Mice medicine Immunology and Allergy Animals Survival rate Messenger RNA Mice Inbred BALB C biology Mice Inbred NZB business.industry Platelet Count Age Factors Antibodies Monoclonal Hematology medicine.disease Interleukin-10 Proteinuria Cytokine Phenotype Antibodies Antinuclear Monoclonal biology.protein Interleukin-2 Interleukin-4 Antibody business CD8 |
| Zdroj: | Immunobiology. 198(4) |
| ISSN: | 0171-2985 |
| Popis: | (NZW × BXSB)Fl (W/BF1) mice spontaneously develop autoimmune diseases, characterized by lymphadenopathy, lupus nephritis, and immune thrombocytopenia associated with various autoanttbodies such as anti-DNA, anti-platelet and anti-cardiolipin antibodies (Abs). In the present study, we investigate the effects of administration of monoclonal Abs (anti-CD4 or anti-CD8 mAb) on the development of autoimmune diseases in W/BF1 mice. MAb was administered from the age of 7 weeks. Prolongation of survival rate and reduction of severity of autoimmune diseases were observed after treatment with anti-CD4 mAb. However, anti-CD8 mAb treatment accelerated the diseases. Serum levels of IFN-γ and IL-10 in old W/BF1 mice were significantly high, whereas IL-4 levels were low in comparison with those of young W/BF1 mice; the expression of mRNA of IFN-γ, IL-4 or IL-10 in CD4 + T cells of old W/BF1 mice was parallel to the serum levels of each cytokine. These observations suggest that CD4 + cells are involved in the development of autoimmune diseases in W/BF1 mice, and that CD8 + cells have a suppressive effect on the development of autoimmune diseases in W/BF1 mice. |
| Databáze: | OpenAIRE |
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