Effects of moisture in compaction of particulate material
| Autor: | John E. Rees, Edward Shotton |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
business.product_category
Materials science Moisture Sodium Drug Compounding Compaction Pharmaceutical Science chemistry.chemical_element Water Humidity Naphthalenes Sodium Chloride Viscosity Light liquid paraffin chemistry Paraffin Particulate material Pressure Die (manufacturing) Composite material Lubricant Powders business Tablets |
| Zdroj: | Journal of pharmaceutical sciences. 60(11) |
| ISSN: | 0022-3549 |
| Popis: | By using an ideal particulate system of crystalline sodium chloride and three liquids—water, decahydronaphthalene, and light liquid paraffin—the role of moisture in the compaction process was investigated. Interrelated effects of liquid at the die wall boundary and within the compact are discussed. Although differences in the behavior of the three liquids could be attributed partly to the viscosity difference, water apparently exerted a boundary lubricant effect in addition to hydrodynamic properties. Despite its lower viscosity, water was, therefore, a more effective lubricant than light liquid paraffin. In general decahydronaphthalene adversely affected the compaction process. Cumulative changes in the difference between applied and transmitted force during consecutive compressions can be used to assess the lubricant efficiency of materials. |
| Databáze: | OpenAIRE |
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