Spastic diplegia in preterm-born children: Executive function impairment and neuroanatomical correlates

Autor: Andrea Guzzetta, Vittorio Belmonti, Giovanni Cioni, Paola Brovedani, Silvia Perazza, Franco Fabbro, Chiara Pecini, Maria Chiara Di Lieto, Simona Fiori, Anna Maria Chilosi, Elisa Sicola, Cosimo Urgesi
Rok vydání: 2016
Předmět:
Male
Audiology
Neuropsychological Tests
Corpus callosum
Developmental psychology
Corpus Callosum
Executive functions
Executive Function
0302 clinical medicine
Cognition
Spastic diplegia
Developmental and Educational Psychology
Neuroanatomical correlates
Attention
Child
Children
Language
NEPSY-II
Neuropsychological profile
Preterm spastic diplegia
Adolescent
Brain
Cerebral Palsy
Child
Preschool
Cognitive Dysfunction
Female
Humans
Infant
Newborn
Infant
Premature
Leukomalacia
Periventricular
Magnetic Resonance Imaging
Memory
Social Perception
Spatial Processing
Clinical Psychology
Social perception
05 social sciences
Neuropsychology
Psychology
050104 developmental & child psychology
medicine.medical_specialty
03 medical and health sciences
Neuroimaging
medicine
0501 psychology and cognitive sciences
Preschool
Premature
Periventricular
Periventricular leukomalacia
Infant
Newborn
medicine.disease
nervous system
030217 neurology & neurosurgery
Leukomalacia
Zdroj: Research in developmental disabilities. 61
ISSN: 1873-3379
Popis: Background The neuropsychological literature on preterm-born children with spastic diplegia due to periventricular leukomalacia is convergent in reporting deficits in non-verbal intelligence and in visuo-spatial abilities. Nevertheless, other cognitive functions have found to be impaired, but data are scant and not correlated with neuroimaging findings. Aims This study analyzes the neuropsychological strengths and weaknesses in preterm-born children with spastic diplegia (pSD) and their relationships with neuroanatomical findings, investigated by a novel scale for MRI classification. Methods and procedures Nineteen children with pSD, mild to moderate upper limb impairment and Verbal IQ > 80, and 38 normal controls were evaluated with a comprehensive neuropsychological battery (NEPSY-II), assessing Attention/Executive Functioning, Language, Memory, Sensorimotor, Social Perception and Visuospatial Processing domains. The MRIs were quantitatively scored for lesion severity. Outcomes and results The results showed that, beyond core visuo-spatial and sensory-motor deficits, impairments in attention and executive functions were present in more than half of the sample, particularly in children with damage to the anterior corpus callosum. Conclusions and implications The findings are discussed in terms of clinical and rehabilitative implications tailored for pSD subgroups diversified for neuropsychological and neuroanatomical characteristics.
Databáze: OpenAIRE
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