A New Neolignan, and the Cytotoxic and Anti-HIV-1 Activities of Constituents from the Roots of Dasymaschalon sootepense
| Autor: | Thaworn Jaipetch, Narong Nuntasaen, Vichai Reutrakul, Chutima Kuhakarn, Surawat Jariyawat, Jitra Limthongkul, Sakchai Hongthong, Pawinee Piyachaturawat, Kanoknetr Suksen |
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| Rok vydání: | 2016 |
| Předmět: |
Anti hiv 1
Anti-HIV Agents Ethyl acetate Annonaceae Plant Science Plant Roots 01 natural sciences Lignans Dasymaschalon sootepense chemistry.chemical_compound Drug Discovery Humans Cytotoxic T cell Cytotoxicity Pharmacology Molecular Structure Traditional medicine Plant Extracts 010405 organic chemistry Anti hiv General Medicine Conocarpan 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry HIV-1 |
| Zdroj: | Natural Product Communications. 11:1934578X1601100 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x1601100628 |
| Popis: | Bioassay-guided isolation from the ethyl acetate extract of Dasymaschalon sootepense roots led to the isolation of twelve compounds including a new dihydrobenzo-furan neolignan, (+)-(2S’,3S)-2,3-dihydro-2-(3,4-dimethoxyphenyl)-3-methylbenzofuran-5-carbaldehyde (5), and eleven known compounds (1-4, and 6-12). The chemical structures and stereochemistry of all the isolated compounds were established by spectroscopic techniques. The known compounds 4 and 6 have been fully characterized spectroscopically, including their absolute configurations. Cytotoxic and anti-HIV-1 reverse transcriptase (RT) activities of compounds 1-3, 5 and 8-12 were determined. Among compounds screened, compounds 2, 3 and 10 displayed weak cytotoxic activity with ED50 values ranging from 9.6-47.5 μM and only compound 2 was found weakly active against HIV-1 RT with an IC50 value of 323.2 μM. |
| Databáze: | OpenAIRE |
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