Impact of anti-HLA antibodies on allogeneic hematopoietic stem cell transplantation outcomes after reduced-intensity conditioning regimens
| Autor: | Xavier Thomas, Marie Y. Detrait, Jihane Fatoum, Giovanna Cannas, Youcef Chelgoum, Stephane Morisset, Nathalie Tedone, Sophie Ducastelle, Valérie Dubois, Fiorenza Barraco, Hélène Labussière, Franck-Emmanuel Nicolini, Lilia Gillis, Mauricette Michallet, Mohamad Sobh |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research Transplantation Conditioning medicine.medical_treatment Graft vs Host Disease Hematopoietic stem cell transplantation Human leukocyte antigen Disease-Free Survival HLA Antigens Genetics medicine Humans Transplantation Homologous Molecular Biology Survival rate Multiple myeloma Aged Autoantibodies Retrospective Studies biology business.industry Incidence Hematopoietic Stem Cell Transplantation Myeloid leukemia Cell Biology Hematology Middle Aged medicine.disease Transplantation Survival Rate surgical procedures operative Hematologic Neoplasms Immunology Acute Disease biology.protein Female Antibody business |
| Zdroj: | Experimental hematology. 40(10) |
| ISSN: | 1873-2399 |
| Popis: | Anti–human leukocyte antigen (HLA) antibodies are associated with several complications in solid organ transplantations, but their impact after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not yet well defined. To evaluate the relevance of anti-HLA antibodies, we have retrospectively analyzed 107 peripheral blood allo-HSCTs after reduced-intensity conditioning regimen between 2005 and 2010. Acute myeloid leukemia and multiple myeloma were the most frequent malignancies in the cohort. The detection of anti-HLA antibodies was systematically performed in all patients before transplantation. Anti-HLA antibodies were present in 24 patients (22%). There was no significant impact of anti-HLA antibodies on engraftment, incidence of relapse, and incidence of acute graft-vs-host disease. The presence of anti-HLA antibodies was associated with significantly worse overall survival ( p = 0.006) and event-free survival ( p = 0.024) after stratification on sex. The 3-year probability of overall survival was 34% without anti-HLA antibodies and 16% in their presence. Patients with anti-HLA antibodies had a higher transplant-related mortality associated with life-threatening vascular complications. Our study supports that anti-HLA antibodies should be tested and considered as an important impacting factor for transplantation outcomes after reduced-intensity conditioning allo-HSCT. We recommend its consideration before allo-HSCT in the donor–recipient selection parameters. |
| Databáze: | OpenAIRE |
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