Marijuana use and serum testosterone concentrations among U.S. males
| Autor: | Britton Trabert, Katherine A. McGlynn, Michael B. Cook, Jake E. Thistle, Megan Braunlin, Barry I. Graubard, Hubert W. Vesper |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Marijuana Abuse Radioisotope Dilution Technique medicine.medical_specialty Time Factors Health Status Urology Endocrinology Diabetes and Metabolism Marijuana Smoking Article Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Marijuana use Tandem Mass Spectrometry Surveys and Questionnaires Internal medicine mental disorders Humans Medicine Male reproductive system Testosterone Least-Squares Analysis Testicular cancer Serum testosterone 030219 obstetrics & reproductive medicine business.industry Testosterone (patch) Increased testosterone Middle Aged Nutrition Surveys medicine.disease United States Cross-Sectional Studies Reproductive Medicine 030220 oncology & carcinogenesis Multivariate Analysis Linear Models business Chromatography Liquid |
| Zdroj: | Andrology. 5:732-738 |
| ISSN: | 2047-2919 |
| Popis: | Marijuana has been reported to have several effects on the male reproductive system. Marijuana has previously been linked to reduced adult testosterone, however, a study in Denmark reported increased testosterone concentrations among marijuana users. This study was performed to estimate the effect of marijuana use on testosterone in U.S. males. Data on serum testosterone, marijuana use, and covariates for 1577 men from the 2011-2012 U.S. National Health and Nutrition Examination Survey (NHANES) were analyzed. Information on marijuana use was collected by a self-administered computer-assisted questionnaire. Serum testosterone was determined using isotope dilution liquid chromatography tandem mass spectrometry. The effects of marijuana use on serum testosterone concentrations were examined by frequency, duration, and recency of use. Adjusted means and 95% confidence intervals (CI) of serum testosterone across levels of marijuana use were estimated using multiple linear regression weighted by the survey weights. The majority (66.2%) of the weighted study population reported ever using marijuana with 26.6% reporting current marijuana use. There was no difference in serum testosterone between ever users (adjusted mean = 3.69 ng/mL, 95% CI: 3.46, 3.93) and never users (adjusted mean = 3.70 ng/mL, 95% CI: 3.45, 3.98) upon multivariable analysis. However, serum testosterone was inversely associated with time since last regular use of marijuana (p-value for trend = 0.02). When restricted to men aged 18-29 years, this relationship strengthened (p-value for trend0.01), and serum testosterone was also inversely associated with time since last use (p-value for trend0.01), indicating that recency of use, and not duration or frequency, had the strongest relationship with testosterone levels. Serum testosterone concentrations were higher in men with more recent marijuana use. Studies are needed to determine the extent to which circulating testosterone concentrations mediate the relationship of marijuana use with male reproductive outcomes. |
| Databáze: | OpenAIRE |
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