Activities of stromal and immune cells in HPV-related cancers

Autor: Maria Luiza Carneiro Moura Gonçalves Rego Barros, Aldo Venuti, Rita de Cássia Pereira de Lima, Marconi Rego Barros, Antonio Carlos de Freitas, Cristiane Moutinho Lagos de Melo
Rok vydání: 2018
Předmět:
Innate immune response
0301 basic medicine
Cancer Research
Stromal cell
Myeloid-derived suppressor cell (MDSC)
Neutrophils
medicine.medical_treatment
Review
HPV-related cancer
Biology
medicine.disease_cause
lcsh:RC254-282
law.invention
03 medical and health sciences
0302 clinical medicine
Immune system
law
Neoplasms
Tumor Microenvironment
medicine
Animals
Humans
Lack of knowledge
Mast Cells
Papillomaviridae
Innate immune system
Immune evasion
Macrophages
Myeloid-Derived Suppressor Cells
Papillomavirus Infections
Dendritic Cells
Immunotherapy
Cancer-associated fibroblasts (CAFs)
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Killer Cells
Natural
030104 developmental biology
Oncology
Apoptosis
030220 oncology & carcinogenesis
Cancer research
Natural Killer T-Cells
Natural killer cells
Suppressor
Stromal Cells
Carcinogenesis
Zdroj: Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-18 (2018)
ISSN: 1756-9966
DOI: 10.1186/s13046-018-0802-7
Popis: The immune system is composed of immune as well as non-immune cells. As this system is a well-established component of human papillomavirus- (HPV)-related carcinogenesis, high risk human papillomavirus (hrHPV) prevents its routes and mechanisms in order to cause the persistence of infection. Among these mechanisms are those originated from stromal cells, which include the cancer-associated fibroblasts (CAFs), the myeloid-derived suppressor cells (MDSCs) and the host infected cells themselves, i.e. the keratinocytes. These types of cells play central role since they modulate immune cells activities to create a prosperous milieu for cancer development, and the knowledge how such interactions occur are essential for prognostic assessment and development of preventive and therapeutic approaches. Nevertheless, the precise mechanisms are not completely understood, and this lack of knowledge precluded the development of entirely efficient immunotherapeutic strategies for HPV-associated tumors. As a result, an intense work for attaining how host immune response works, and developing of effective therapies has been applied in the last decade. Based on this, this review aims to discuss the major mechanisms of immune and non-immune cells modulated by hrHPV and the potential and existing immunotherapies involving such mechanisms in HPV-related cancers. It is noticed that the combination of immunotherapies has been demonstrated to be essential for obtaining better results, especially because the possibility of increasing the modulating capacity of the HPV-tumor microenvironment has been shown to be central in strengthening the host immune system.
Databáze: OpenAIRE
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