Morphine and codeine are endogenous components of human cerebrospinal fluid
| Autor: | Kazuhiro Oka, A. Donald Finck, Joel D. Kantrowitz, Josef Donnerer, Sydney Spector, George J. Cardinale |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Adolescent Endogeny Pharmacology General Biochemistry Genetics and Molecular Biology Cerebrospinal fluid medicine Humans General Pharmacology Toxicology and Pharmaceutics Child Opioid peptide Aged Aged 80 and over Morphine Codeine Chemistry Antibodies Monoclonal General Medicine Middle Aged Child Preschool Female Acid hydrolysis medicine.drug |
| Zdroj: | Life Sciences. 40:301-306 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(87)90347-x |
| Popis: | We have examined cerebrospinal fluid (CSF) from twelve patients who were not on any medication and found them to contain both morphine and codeine in concentrations of 2 to 339 fmol/ml. These are comparable to the concentration of opioid peptides in spinal fluid. Both morphine and codeine are present mainly in conjugated form from which the free alkaloids can be released by acid hydrolysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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