Advances and highlights in asthma in 2021
| Autor: | Catalina Cojanu, Ibon Eguiluz-Gracia, Magdalena Zemelka-Wiacek, Ioana Agache, Alexandru Laculiceanu, Marek Jutel, Cezmi A. Akdis, Stefano Del Giacco, Anna Kosowska |
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| Přispěvatelé: | University of Zurich, Agache, Ioana |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Severe asthma Immunology Asthma treatment 610 Medicine & health Context (language use) Panel report exacerbations 10183 Swiss Institute of Allergy and Asthma Research Artificial Intelligence immune system diseases Pandemic medicine Humans Immunology and Allergy guidelines Intensive care medicine Asthma 2403 Immunology Biological Products business.industry biomarkers asthma medicine.disease Planetary health respiratory tract diseases Clinical trial endotypes 2723 Immunology and Allergy business |
| Zdroj: | Allergy. 76:3390-3407 |
| ISSN: | 1398-9995 0105-4538 |
| DOI: | 10.1111/all.15054 |
| Popis: | Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality real-world evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective. |
| Databáze: | OpenAIRE |
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