Serum levels of sex hormone-binding globulin (SHBG) are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men
| Autor: | Huibert A. P. Pols, Majon Muller, Diederick E. Grobbee, Yvonne T. van der Schouw, Frank H. de Jong, Frank H. Pierik, Louis Gooren, Willem de Ronde, Rob F. A. Weber |
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| Přispěvatelé: | Internal Medicine, Public Health, University of Groningen, Internal medicine, ACS - Atherosclerosis & ischemic syndromes |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male LH medicine.medical_specialty Aging BOYS Bound testosterone Cross-sectional study medicine.drug_class Endocrinology Diabetes and Metabolism Biological Availability INFANTS METABOLIC-CLEARANCE RATE RESPONSIVENESS Endocrinology Sex hormone-binding globulin AGE Internal medicine Sex Hormone-Binding Globulin polycyclic compounds Medicine Humans Testosterone NEGATIVE FEEDBACK reproductive and urinary physiology HUMAN-PLASMA Aged Aged 80 and over biology business.industry Infant Newborn Plasma levels Middle Aged Androgen ANDROGEN Cross-Sectional Studies Ageing GONADOTROPIN biology.protein Linear Models Gonadotropin business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Clinical Endocrinology, 62(4), 498-503. Wiley-Blackwell Publishing Ltd Clinical Endocrinology, 62(4), 498-503. Wiley De Ronde, W, Van Der Schouw, Y T, Pierik, F H, Pols, H A P, Muller, M, Grobbee, D E, Gooren, L J G, Weber, R F A & De Jong, F H 2005, ' Serum levels of sex hormone-binding globulin (SHBG) are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men ', Clinical Endocrinology, vol. 62, no. 4, pp. 498-503 . https://doi.org/10.1111/j.1365-2265.2005.02252.x Clinical Endocrinology, 62(4), 498-503. Wiley-Blackwell |
| ISSN: | 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2005.02252.x |
| Popis: | Objective It is generally accepted that SHBG decreases the bioavailability and activity of testosterone (T). In in vitro experiments increased levels of SHBG will be associated with decreased levels of non-SHBG bound testosterone (non-SHBG-T). However, in vivo SHBG can alter both production and clearance rates and thus plasma levels of T.Design and patients In order to study the effect of SHBG on the levels of non-SHBG-T in vivo in the presence of an active hypothalamo-pituitary-gonadal (HPG) axis we conducted a cross sectional study in 400 healthy adult men with an age range of 40-80 years and in 106 newborn boys.Measurements In both groups, regression coefficients (beta) and partial correlation coefficients (r) were calculated for the relationship between SHBG and T or non-SHBG-T. Adult men were divided into age groups per decade (40-50 years, 51-60 years, 61-70 years and 71-80 years) to study possible differences in the impact of SHBG on the level of non-SHBG-T throughout ageing.Results Higher levels of SHBG were associated with higher levels of total testosterone in neonates (beta = 0.02 +/- 0.004, r = 0.44, P Conclusions In contrast to general belief, SHBG levels barely influence levels of non-SHBG-bound testosterone both in male newborns and healthy adult men: the influence, if any, is positive. Consequently the age related increase of SHBG does not account for the age related decline in non-SHBG-T in healthy adult men. |
| Databáze: | OpenAIRE |
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