Feasibility of Extracorporeal Shock Wave Myocardial Revascularization Therapy for Post-Acute Myocardial Infarction Patients and Refractory Angina Pectoris Patients
| Autor: | Masahiro Myojo, Masao Daimon, Masafumi Watanabe, Issei Komuro, Jiro Ando, Masae Uehara |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Myocardial Infarction 030204 cardiovascular system & hematology Revascularization Angina Pectoris High-Energy Shock Waves Angina 03 medical and health sciences 0302 clinical medicine Cardiac magnetic resonance imaging Internal medicine Myocardial Revascularization medicine Humans Prospective Studies cardiovascular diseases 030212 general & internal medicine Myocardial infarction Aged Ejection fraction Ventricular Remodeling medicine.diagnostic_test Troponin T business.industry Percutaneous coronary intervention General Medicine Middle Aged medicine.disease Heart failure Cardiology Feasibility Studies Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Heart Journal. 58:185-190 |
| ISSN: | 1349-3299 1349-2365 |
| Popis: | Extracorporeal shockwave myocardial revascularization (ESMR) is one of the new treatment options for refractory angina pectoris (RAP), and some studies have indicated its effectiveness. A single-arm prospective trial to assess the feasibility of ESMR using Cardiospec for patients with post-acute myocardial infarction (AMI) and RAP was designed and performed. The patients were treated with 9 sessions of ESMR to the ischemic areas for 9 weeks. The feasibility measures included echocardiography; cardiac magnetic resonance imaging; troponin T, creatine kinase-MB (CK-MB), and brain natriuretic peptide testing; and a Seattle Angina Questionnaire (SAQ) survey. Three post-AMI patients and 3 RAP patients were enrolled. The post-AMI patients had already undergone revascularization with percutaneous coronary intervention (PCI) in the acute phase. In two patients, adverse events requiring admission occurred: one a lumbar disc hernia in a post-AMI patient and the other congestive heart failure resulting in death in an RAP patient. No apparent elevations in CK-MB and troponin T levels during the trial were observed. Echocardiography revealed no remarkable changes of ejection fraction; however, septal E/E' tended to decrease after treatments (11.6 ± 4.8 versus 9.2 ± 2.8, P = 0.08). Concerning the available SAQ scores for two RAP patients, one patient reported improvements in angina frequency and treatment satisfaction and the other reported improvements in physical limitations and angina stability. In this feasibility study, ESMR seems to be a safe treatment for both post-AMI patients and RAP patients. The efficacy of ESMR for post-AMI patients remains to be evaluated with additional studies. |
| Databáze: | OpenAIRE |
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