Naphthalene glycosides in the Thai medicinal plant Diospyros mollis
| Autor: | Kenji Watanabe, Keisuke Watanabe, Kaoru Umehara, Takaharu Suwama, Prathan Luecha, Orawan Monthakantirat, Hiroshi Noguchi |
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| Rok vydání: | 2017 |
| Předmět: |
Diospyros mollis
Stereochemistry Naphthalenes 01 natural sciences Terpene chemistry.chemical_compound Triterpene Glycosides Naphthalene chemistry.chemical_classification Plants Medicinal biology 010405 organic chemistry Plant Extracts Glycoside Diospyros biology.organism_classification Thailand Naphthoquinone 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry chemistry Molecular Medicine Ebenaceae |
| Zdroj: | Journal of natural medicines. 72(1) |
| ISSN: | 1861-0293 |
| Popis: | This study evaluated methanol extracts from the leaves and branches of the Thai medicinal plant Diospyros mollis (Ebenaceae). Seven triterpenes and 22 aromatic compounds, including five new compounds, were isolated, and their structures were determined. The new compounds had the following structures: diospyrol glycoside (makluoside A, 1), 8,8'-di-O-6-β-D-apiofuranosyl-β-D-glucopyranosyl-6,6'-dimethyl-2,3'-binaphthalene-1-ol-1',4'- dione (makluoside B, 2), and 3-methyl-1,8- naphthalenediol glycosides (makluosides C-E, 3-5). Makluoside B is the first example of a naphthoquinone glycoside that has both a 3-methyl-1,8-naphthalenediol unit and a 5-hydroxy-7-methyl-1,4-naphthoquinone unit. The hyaluronidase inhibitory activity of the isolates was evaluated, revealing that one of the triterpene derivatives possessed moderate inhibitory activity. |
| Databáze: | OpenAIRE |
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