Nitroxyl radicals decrease toxicity of cytostatic agents
| Autor: | R F Diatchkovskaya, N. P. Konovalova, V N Varfolomeev, Volkova Lm |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Cancer Research
Free Radicals Cyclophosphamide Cytostatic agents Antineoplastic Agents Pharmacology P450 cytochrome Mice Cytochrome P-450 Enzyme System medicine Animals Drug Interactions Pharmacology (medical) Thiophosphamide Dose-Response Relationship Drug Mercaptopurine Chemistry Nitroxyl radicals Oncology Toxicity Female Nitrogen Oxides Thiotepa medicine.drug |
| Zdroj: | Anti-Cancer Drugs. 2:591-596 |
| ISSN: | 0959-4973 |
| Popis: | Nitroxyl radicals of a series of piperidineoxyles and pirrolinoxyles increase the tolerance of experimental animals to the injection of otherwise lethal doses of anti-tumor cytostatic agents. Simultaneous injection of nitroxyl radicals in different doses with 6-mercaptopurine, thiophosphamide, cyclophosphamide and the other cytostatic agents results in decreased toxicity and survival of animals. Nitroxyl radicals normalize the level of the oxidized form of P450 cytochrome that is decreased by the injection of lethal doses of cytostatic agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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