Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations

Autor:	Gaëlle Frenois-Veyrat, Franck Gallardo, Olivier Gorgé, Elie Marcheteau, Olivier Ferraris, Artem Baidaliuk, Anne-Laure Favier, Cécile Enfroy, Xavier Holy, Jérémy Lourenco, Rhéa Khoury, Flora Nolent, Douglas W. Grosenbach, Dennis E. Hruby, Audrey Ferrier, Frédéric Iseni, Etienne Simon-Loriere, Jean-Nicolas Tournier
Rok vydání:	2022
Předmět:	Microbiology (medical) Immunology Benzamides Genetics Humans Cell Biology Monkeypox Monkeypox virus Isoindoles Applied Microbiology and Biotechnology Microbiology United States
Zdroj:	Nature microbiology. 7(12)
ISSN:	2058-5276
Popis:	The ongoing monkeypox virus (MPXV) outbreak is the largest ever recorded outside of Africa. We isolated and sequenced a virus from the first clinical MPXV case diagnosed in France (May 2022). We report that tecovirimat (ST-246), a US Food and Drug Administration approved drug, is efficacious against this isolate in vitro at nanomolar concentrations, whereas cidofovir is only effective at micromolar concentrations. Our results support the use of tecovirimat in ongoing human clinical trials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb5665a4d1ab240871608861f4feca3 https://pubmed.ncbi.nlm.nih.gov/36344621 Zobrazit plný text záznamu Full text from SpringerLink