Stereoselective palladium-catalyzed allylic alkylations of peptideamide enolates
| Autor: | Uli Kazmaier, Swarup Datta |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Allylic rearrangement Natural product Alkylation Molecular Structure Chemistry Organic Chemistry chemistry.chemical_element Stereoisomerism Peptide Amides Biochemistry Combinatorial chemistry Catalysis Allyl Compounds chemistry.chemical_compound Yield (chemistry) Amide Organic chemistry Stereoselectivity Physical and Theoretical Chemistry Peptides Palladium |
| Zdroj: | Org. Biomol. Chem.. 9:872-880 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c0ob00628a |
| Popis: | Pd-catalyzed allylations are an excellent tool for stereoselective peptide modifications, being clearly superior to normal alkylations. The reactions proceed not only in high yield, but also high regio- and diastereoselectivities, and trans-products are formed exclusively. Therefore, this is a powerful synthetic tool for natural product and drug synthesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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