Anti-infectious Activity of Tryptophan Metabolites in the L-Tryptophan-L-Kynurenine Pathway
| Autor: | Koji Narui, Shinichi Takamoto, Noboru Motomura, Masanori Sasatsu, Norihisa Noguchi, Aya Saito, Kin-ya Kubo, Kazuhiro Kakimi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Time Factors Pharmaceutical Science Biology Iron Chelating Agents medicine.disease_cause Microbiology Inhibitory Concentration 50 chemistry.chemical_compound Anthranilic acid medicine Indoleamine-Pyrrole 2 3 -Dioxygenase Picolinic Acids Kynurenine Pharmacology Dose-Response Relationship Drug Tryptophan General Medicine Antimicrobial Anti-Bacterial Agents Transplantation Tryptophan Metabolite chemistry Staphylococcus aureus Antibacterial activity Quinolinic acid |
| Zdroj: | Biological and Pharmaceutical Bulletin. 32:41-44 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.32.41 |
| Popis: | To study the anti-infectious effect of a vascular allograft, the antimicrobial activity of tryptophan metabolites mediated by indoleamine 2,3-dioxygenase was determined. The growth of methicillin-resistant Staphylococcus aureus (MRSA) over 10 h in extracts from post-transplantation vascular allograft was significantly slower than that of extracts from non-transplantation vascular allograft regardless of the presence of tryptophan (p |
| Databáze: | OpenAIRE |
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