A longitudinal study of the impact of marijuana on adult memory function: Prenatal, adolescent, and young adult exposures

Autor: Gale A. Richardson, Lidush Goldschmidt, Nancy L. Day, Jennifer A. Willford, Natacha M. De Genna
Rok vydání: 2020
Předmět:
Male
Longitudinal study
Adolescent
media_common.quotation_subject
010501 environmental sciences
Neuropsychological Tests
Toxicology
01 natural sciences
Article
Cohort Studies
03 medical and health sciences
Cellular and Molecular Neuroscience
Young Adult
0302 clinical medicine
Developmental Neuroscience
Memory
Pregnancy
mental disorders
Medicine
Humans
Cognitive skill
Longitudinal Studies
Young adult
Age of Onset
0105 earth and related environmental sciences
media_common
Intelligence Tests
Memory Disorders
biology
business.industry
Learning Disabilities
Wechsler Scales
Wechsler Adult Intelligence Scale
Abstinence
biology.organism_classification
Child development
Prenatal Exposure Delayed Effects
Female
Marijuana Use
Cannabis
Childhood memory
business
030217 neurology & neurosurgery
Clinical psychology
Zdroj: Neurotoxicol Teratol
ISSN: 1872-9738
Popis: More Americans are using marijuana than in previous decades but there are concerns over its long-term impact on cognitive functioning, especially memory. The literature on marijuana use and cognitive functioning is mixed, with some studies showing recovery of functioning upon abstinence from the drug and others showing long-term effects that persist. The latter seems especially true for individuals who initiate marijuana at a younger age and engage in more chronic patterns of use. The goal of the current study is to use prospectively collected data on young adults from a prenatal cohort to determine if there is an effect of early and/or current marijuana use on young adult memory, controlling for prenatal exposure to marijuana use, childhood memory deficits, and other significant covariates of memory functioning. At the 22-year follow-up phase of the Maternal Health Practices and Child Development (MHPCD) study, 524 young adults (58% Black, 42% White, 52% female) completed the Wechsler Memory Scale-III. Multiple regression analyses and structural equation modeling were used to determine the effect of marijuana exposure during gestation, early adolescence, and young adulthood on young adult memory function. Results indicated that initiating marijuana use before age 15 placed young adults at greater risk of memory deficits, even after controlling for childhood memory and current marijuana use. First trimester marijuana exposure also indirectly predicted young adult memory function via childhood memory deficits and early initiation of marijuana. These findings highlight the risk of prenatal marijuana exposure and early initiation of marijuana for long-term memory function in adulthood.
Databáze: OpenAIRE
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