Selenium and viral infection: are there lessons for COVID-19?
| Autor: | Giovanna Bermano, Derry K. Mercer, Catherine Méplan, John E. Hesketh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) GPX glutathione peroxidase Nrf2 nuclear factor erythroid 2-related factor 2 CVB coxsackievirus B3 UPR unfolded protein response Interferon Epidemiology Severe acute respiratory syndrome coronavirus 2 Micronutrients TXNRD thioredoxin reductase Letter to the Editor COVID-19 coronavirus disease 2019 education.field_of_study Nutrition and Dietetics Selenoprotein S NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells Micronutrient NOX NADPH oxidase SELENOS selenoprotein S Redox status Virus Diseases SELENOF selenoprotein F RNA Viral IV influenza virus Animal studies medicine.symptom Oxidation-Reduction Systematic Review and Meta-Analysis medicine.drug medicine.medical_specialty Population Nutritional Status Inflammation Biology SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 ER endoplasmic reticulum 03 medical and health sciences Selenium ROS reactive oxygen species Stress Physiological medicine Animals Humans IFN interferon education 030109 nutrition & dietetics SARS-CoV-2 MERS Middle East respiratory syndrome COVID-19 medicine.disease 030104 developmental biology Viral infection Immunology Middle East respiratory syndrome biology.gene |
| Zdroj: | The British Journal of Nutrition British Journal of Nutrition |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | Se is a micronutrient essential for human health. Sub-optimal Se status is common, occurring in a significant proportion of the population across the world including parts of Europe and China. Human and animal studies have shown that Se status is a key determinant of the host response to viral infections. In this review, we address the question whether Se intake is a factor in determining the severity of response to coronavirus disease 2019 (COVID-19). Emphasis is placed on epidemiological and animal studies which suggest that Se affects host response to RNA viruses and on the molecular mechanisms by which Se and selenoproteins modulate the inter-linked redox homeostasis, stress response and inflammatory response. Together these studies indicate that Se status is an important factor in determining the host response to viral infections. Therefore, we conclude that Se status is likely to influence human response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and that Se status is one (of several) risk factors which may impact on the outcome of SARS-CoV-2 infection, particularly in populations where Se intake is sub-optimal or low. We suggest the use of appropriate markers to assess the Se status of COVID-19 patients and possible supplementation may be beneficial in limiting the severity of symptoms, especially in countries where Se status is regarded as sub-optimal. |
| Databáze: | OpenAIRE |
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