Heart rate variability in cocaine-exposed newborn infants
| Autor: | Elizabeth S Kaufman, Rose A. Harcar-Sevcik, Dennis M. Super, Ann Salvator, Lynn T. Singer, Sudhir Ken Mehta, Linda Goetz Fradley, David Connuck |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Pediatrics Heart disease Group ii Sudden death Asymptomatic Autonomic control Cocaine-Related Disorders Cocaine Heart Rate Pregnancy Risk Factors Internal medicine medicine Heart rate variability Humans Maternal-Fetal Exchange business.industry Infant Newborn Sudden infant death syndrome medicine.disease Pregnancy Complications Increased risk Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Sudden Infant Death |
| Zdroj: | American heart journal. 142(5) |
| ISSN: | 1097-6744 |
| Popis: | Infants born to cocaine-using mothers have a 3- to 8-fold increase in sudden infant death syndrome. Its underlying cause, in part, may be attributed to abnormal autonomic function. We proposed to study heart rate variability, reflecting autonomic control of the heart, in cocaine-exposed infants.From 1997 to 2000, we studied 217 asymptomatic, term infants, of whom 68 had intrauterine cocaine exposure (group I). Their data were compared with infants exposed to drugs other than cocaine (group II, n = 77) and no drugs (group III, n = 72). Twenty-four-hour heart rate variability was measured within 72 hours of birth.Cocaine-exposed infants, as compared with the 2 control groups, had an overall significant decrease (P.05) in global heart rate variability and a lower standard deviation of all valid N-N intervals in the recording (41.9 +/- 1.4 ms vs 47.6 +/- 1.3 ms and 46.9 +/- 1.3 ms, respectively). Vagal parameters such as high-frequency power and the square root of the mean of the squared differences between adjacent N-N intervals were also lower in newborns with heavy in utero cocaine exposure.Decreased heart rate variability was seen in cocaine-exposed infants. Whether low heart rate variability is a marker for increased risk of sudden death in infants (as it is in adults with structural heart disease) is unknown and requires further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect