Addition of topical pimecrolimus to once-daily mid-potent steroid confers no short-term therapeutic benefit in the treatment of severe atopic dermatitis; a randomized controlled trial
| Autor: | Adelaide A Hebert, Thomas Hultsch, P. R. Gallagher, C. McCormick, Anne Parneix-Spake, Jonathan M. Spergel, Mark Boguniewicz, Amy S. Paller |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Anti-Inflammatory Agents Dermatology Administration Cutaneous Severity of Illness Index Eczema Area and Severity Index Tacrolimus Fluticasone propionate Dermatitis Atopic law.invention Atopy Pimecrolimus Double-Blind Method Randomized controlled trial law medicine Humans Child Aged Fluticasone business.industry Atopic dermatitis Middle Aged medicine.disease Androstadienes Regimen Treatment Outcome Child Preschool Drug Therapy Combination Female Dermatologic Agents business medicine.drug |
| Zdroj: | British Journal of Dermatology. 157:378-381 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.2007.08001.x |
| Popis: | Summary Background Combination therapy with pimecrolimus cream 1%, a topical calcineurin inhibitor (TCI), and fluticasone propionate cream 0·05% (FP), a mid-potency topical corticosteroid, may have a synergistic effect for treatment of atopic dermatitis (AD) because their mechanism of action differs. Objectives To assess the efficacy of concomitant pimecrolimus twice daily/FP once daily vs. vehicle twice daily/FP once daily in patients with severe AD. Methods An exploratory, 2-week, double-blind, randomized, within-patient study was conducted (n = 45). Two target areas of similar severity, size and location were assessed. Assessments included the modified Eczema Area and Severity Index (0–12 scale) (primary variable), localized investigator global assessment (0–4 scale) and Patients’ Self-Assessment of Disease Severity (0–4 scale). Results Data for all variables were similar for the TCI/FP and vehicle/FP treatments. Conclusions The efficacy observed for treatment of severe AD flares with this TCI/FP combination regimen was equivalent to that of vehicle/FP. |
| Databáze: | OpenAIRE |
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