Angiotensin II Type 2 Receptor Vasoactivity in Internal Mammary Arteries of Patients With Coronary Artery Disease
| Autor: | R. M. A van de Wal, H.W.M. Plokker, Georg Nickenig, W. J. Morshuis, D. J. Van Veldhuisen, W. H. Van Gilst, P. van der Harst, Hendrik Buikema, Lodewijk J. Wagenaar, Sven Wassmann, A. A. Voors |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Angiotensin receptor Pyridines Vasodilator Agents Gene Expression Tetrazoles Vasodilation Coronary Artery Disease Phenylephrine Vasoconstrictor Agents Receptor Mesenteric arteries Aged 80 and over Angiotensin II Imidazoles Middle Aged Receptor antagonist medicine.anatomical_structure cardiovascular system Female Cardiology and Cardiovascular Medicine Oligopeptides hormones hormone substitutes and hormone antagonists medicine.drug Adult medicine.medical_specialty medicine.drug_class In Vitro Techniques Receptor Angiotensin Type 2 Receptor Angiotensin Type 1 Internal medicine medicine Humans Mammary Arteries Phentolamine Adrenergic alpha-Antagonists Aged Pharmacology Angiotensin II receptor type 1 Sodium Nitrite business.industry Biphenyl Compounds Acetylcholine Candesartan Endocrinology Benzimidazoles business Angiotensin II Type 1 Receptor Blockers |
| Zdroj: | Journal of Cardiovascular Pharmacology. 50:372-379 |
| ISSN: | 0160-2446 |
| Popis: | Background: Several animal studies suggested that the angiotensin II type 2 (AT2) receptor subtype mediates vasodilation, yet the results in human arteries are less well described and more inconsistent. Therefore, we evaluated the role of the AT2 receptor stimulation on the vasotonus of human internal mammary arteries. Methods: Internal mammary arteries were obtained from 50 patients undergoing coronary bypass surgery. The expression of angiotensin II type I (AT1) receptor and AT2 receptor mRNA was determined by using real-time polymerase chain reaction. In addition, angiotensin II and CGP42112A concentration-response curves (concentration range: 10(-10) M to 10(-6) M) were constructed in absence or presence of candesartan (10(-5) M) and/or the AT2 receptor-antagonist PD-123319 (10-6 M) and/or the a receptor antagonist phentolamine. Results: Both AT1 and AT2 receptor protein and mRNA were detected, and higher AT2 receptor mRNA expression levels were associated with increased contractile response to angiotensin II. Angiotensin II caused vasoconstriction up to 41.1 +/- 6.5% of the maximal response to phenylephrine, and PD123319 significantly reduced this response (28.6 +/- 9.6%, P |
| Databáze: | OpenAIRE |
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