Effects of Herbal Formulas Bojungikgi-tang and Palmijihwang-hwan on Inflammation in RAW 264.7 Cells and the Activities of Drug-Metabolizing Enzymes in Human Hepatic Microsomes
| Autor: | Hyeun-Kyoo Shin, Seong Eun Jin, Hyekyung Ha |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Drug Compounding
Anti-Inflammatory Agents Medicine (miscellaneous) Inflammation Pharmacology UDP Glucuronosyltransferase Mice Cytochrome P-450 Enzyme System medicine Animals Cytochrome P-450 Enzyme Inhibitors Humans Enzyme Inhibitors Glucuronosyltransferase RAW 264.7 Cells Herb-drug interactions Nutrition and Dietetics Plant Extracts Chemistry Macrophages Anti inflammation ANT Drug metabolizing enzymes Microsomes Liver medicine.symptom Hepatic microsome |
| Zdroj: | Journal of Medicinal Food. 21:1173-1187 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2017.4123 |
| Popis: | In the present study, Bojungikgi-tang (BJIKT: Buzhongyiqi-tang, Hochuekki-to) and Palmijihwang-hwan (PMJHH: Baweidìhuang-wan, Hachimijio-gan), traditional herbal formulas, investigated anti-inflammatory efficacies in murine macrophage cell line and the influence on the activities of drug-metabolizing enzymes (DMEs). The anti-inflammatory potentials of the herbal formulas were evaluated to inhibit the production of the inflammatory mediators and cytokines and the protein expression of inducible nitric oxide and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-treated RAW 264.7 cells. The activities of the major human DMEs, cytochrome P450 isozymes (CYP450s) and UDP-glucuronosyltransferase isozymes (UGTs), were measured by in vitro enzyme assay systems. BJIKT and PMJHH significantly suppressed the prostaglandin E |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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