False-Negative Results in Lung Cancer Screening—Evidence and Controversies
| Autor: | Mario Silva, Emily C. Bartlett, Matthew E.J. Callister, Anand Devaraj |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms Computed tomography 03 medical and health sciences 0302 clinical medicine Radiologic Evaluation medicine Humans Mass Screening Overdiagnosis Intensive care medicine Lung cancer Lung Early Detection of Cancer medicine.diagnostic_test business.industry nutritional and metabolic diseases medicine.disease nervous system diseases 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Tomography X-Ray Computed business Lung cancer screening |
| Zdroj: | Journal of Thoracic Oncology. 16:912-921 |
| ISSN: | 1556-0864 |
| DOI: | 10.1016/j.jtho.2021.01.1607 |
| Popis: | Identifying false-negative cases is an important quality metric in lung cancer screening, but it has been infrequently and variably reported in previous studies. Although as a proportion of all screening participants, false-negative cases are uncommon, such cases may constitute a substantial proportion of all lung cancers diagnosed (up to 15%) within a screening program. This article reviews the impact and causes of false-negative lung cancer screening tests, including those related to radiologic evaluation, nodule management protocols, and management decisions made by multidisciplinary teams. Following a review of data from international screening studies, this article discusses the controversies within the screening literature surrounding the definition and classification of a false-negative lung cancer screening test and how data on false-negative rates should be captured and recorded. Challenges, such as avoiding overly cautious surveillance of lung nodules while minimizing overdiagnosis and investigation of indolent or benign lesions, are considered. Finally, the advantages and disadvantages of different approaches to dealing with false-negative results in lung cancer screening are discussed. |
| Databáze: | OpenAIRE |
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