High risk of pituitary dysfunction due to aneurysmal subarachnoid haemorrhage: a prospective investigation of anterior pituitary function in the acute phase and 12 months after the event
| Autor: | Fahrettin Kelestimur, Ahmet Turan Dagli, Fatih Tanriverdi, Felipe F. Casanueva, Kursad Unluhizarci, Ahmet Selcuklu, Zuleyha Karaca |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System Pituitary gland medicine.medical_specialty Subarachnoid hemorrhage Adolescent Endocrinology Diabetes and Metabolism Pituitary-Adrenal System Young Adult Endocrinology Adrenocorticotropic Hormone Anterior pituitary Internal medicine medicine Humans cardiovascular diseases Aged business.industry Retrospective cohort study Middle Aged Subarachnoid Hemorrhage medicine.disease nervous system diseases medicine.anatomical_structure Growth Hormone Pituitary Gland Female Subarachnoid haemorrhage Pituitary dysfunction business Gonadotropins Hormone Endocrine gland |
| Zdroj: | Clinical Endocrinology. 67:931-937 |
| ISSN: | 1365-2265 0300-0664 |
| Popis: | Summary Objective Recent investigations have provided evidence for a high prevalence of pituitary dysfunction in patients with subarachnoid haemorrhage (SAH). However, apart from one study, all of the previous data were obtained from retrospective studies. To our knowledge there is no previously reported study in which pituitary function was investigated in the same patients immediately after SAH and 12 months later. The aim of this study was to understand the prevalence and progression of anterior pituitary hormone deficiencies both in the acute phase of SAH and 12 months after the event. Patients and design Twenty-two SAH patients (11 men, 11 women) were included in the study. Pituitary function was evaluated in the early acute phase (within 24 h of admission) and after 12 months. Results Pituitary hormone deficiencies in the acute phase were as follows: 31·8% had gonadotrophin, 22·7% had ACTH and 22·7% had GH deficiencies. At 12 months after SAH: 0·0% had gonadotrophin, 13·6% had ACTH and 36·4% had GH deficiencies. Overall, after 12 months, pituitary hormone deficiencies recovered in 15 (68·2%) patients and new-onset pituitary hormone deficiencies were present in nine (40·9%) patients. Conclusions GH deficiency (GHD) was the most common pituitary deficit at 12 months after SAH and the majority of the patients (87·5%) had isolated GHD. During the 12-month follow-up, pituitary function was found to either improve or worsen in a considerable number of patients. |
| Databáze: | OpenAIRE |
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