Salivary opiorphin in dental pain: A potential biomarker for dental disease
| Autor: | Cigdem Sonmez, Selen İnce Yusufoğlu, Mahmut Sertac Ozdogan, Sinan Yasin Ertem, Mustafa Gungormus, Metin Orhan |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Nociception 0301 basic medicine Saliva medicine.medical_specialty Turkey Enzyme-Linked Immunosorbent Assay Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Facial Pain Internal medicine Oral and maxillofacial pathology medicine Humans Salivary Proteins and Peptides General Dentistry Pain Measurement Inflammation Tooth Nonvital Periodontitis Analysis of Variance business.industry Opiorphin Pulpitis Repeated measures design Toothache 030206 dentistry Cell Biology General Medicine Middle Aged medicine.disease 030104 developmental biology Otorhinolaryngology Potential biomarkers Symptomatic irreversible pulpitis Female business Oligopeptides Biomarkers Periapical Periodontitis medicine.drug |
| Zdroj: | Archives of Oral Biology. 99:15-21 |
| ISSN: | 0003-9969 |
| DOI: | 10.1016/j.archoralbio.2018.12.006 |
| Popis: | Objectives Opiorphin is a recently discovered peptide shown to inhibit the enkephalin-degrading enzymes and prolong the effects of enkephalins. Although opiorphin is found in high concentrations in saliva, the relationship between salivary opiorphin and orofacial pains is not yet fully understood. We aimed to determine salivary opiorphin concentrations in dental pain related to symptomatic irreversible pulpitis (SIP), and symptomatic apical periodontitis (SAP). Design 39 patients participated in this study. The participants were categorized into SIP and SAP based on their diagnosis. All the patients were treated with root canal treatment. Saliva specimens were collected, and pain levels were recorded at pre-treatment, 7 days post-treatment and 30 days post-treatment. Saliva opiorphin levels were measured using a commercially available ELISA kit. Pre-treatment and post-treatment opiorphin levels were evaluated using repeated measures ANOVA. Correlations between VAS scores, opiorphin levels and age were evaluated using Spearman’s Rank Correlation. Results The average saliva opiorphin level pre-treatment, 7 days post-treatment and 30 days post-treatment were 31.28 ± 7.10 ng/ml, 20.41 ± 2.67 ng/ml and 18.61 ± 2.05 ng/ml respectively. Significantly higher pre-treatment opiorphin levels were observed in the SIP group compared to the SAP group. A strong correlation was observed between the pre-treatment pain levels and the saliva opiorphin concentrations. Conclusions Our findings indicate that saliva opiorphin levels increase in inflammation related dental pain. The level of salivary opiorphin is strongly correlated with the reported level of pain. The extent of the inflammation (pulpal vs. periodontal) also affects the opiorphin level. |
| Databáze: | OpenAIRE |
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