Cell size and growth rate are major determinants of replicative lifespan
| Autor: | Arkadi Manukyan, Holly Mead, Wesley Lane, Huzefa Dungrawala, Lesley Abraham, Hui Hua, Jingye Yang, Brandt L. Schneider, Jill Wright |
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| Rok vydání: | 2011 |
| Předmět: |
Cell division
Cell Cell Enlargement Biology medicine.disease_cause Article Report Yeasts medicine Growth rate Molecular Biology Cellular Senescence Cell Proliferation Cell Size Mutation Cell growth Cell Biology Data science Yeast Cell biology medicine.anatomical_structure Cell aging Cell Division Developmental Biology |
| Zdroj: | Cell Cycle. 10:144-155 |
| ISSN: | 1551-4005 1538-4101 |
| DOI: | 10.4161/cc.10.1.14455 |
| Popis: | Yeast cells, like mammalian cells, enlarge steadily as they age. Unabated cell growth can promote cellular senescence; however, the significance of the relationship between size and cellular lifespan is not well understood. Herein, we report a genetic link between cell size, growth rate and lifespan. Mutations that increase cell size concomitantly increase growth rate and decrease lifespan. As a result, large cells grow, divide and age dramatically faster than small cells. Conversely, small cell mutants age slowly and are long-lived. Investigation of the mechanisms involved suggests that attainment of a maximal size modulates lifespan. Indeed, cumulative results revealed that life expectancy is size-dependent, and that the rate at which cells age is determined in large part by the amount of cell growth per generation. |
| Databáze: | OpenAIRE |
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