Clinical and bacterial features of Group B streptococci with reduced penicillin susceptibility from respiratory specimens: a case–control study
| Autor: | Naoya Nishiyama, Masao Tateyama, Kohei Uechi, Takeshi Kinjo, Jiro Fujita, Masashi Nakamatsu, Gretchen Parrott |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Microbiology (medical) Serotype medicine.medical_specialty Penicillin Resistance Microbial Sensitivity Tests Penicillins Drug resistance medicine.disease_cause Group B Streptococcus agalactiae Microbiology Young Adult Antibiotic resistance Medical microbiology Streptococcal Infections Humans Medicine Respiratory Tract Infections Phylogeny Aged Retrospective Studies Aged 80 and over business.industry General Medicine Middle Aged Anti-Bacterial Agents Penicillin Infectious Diseases Case-Control Studies Multilocus sequence typing Female business medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 41:1-8 |
| ISSN: | 1435-4373 0934-9723 |
| Popis: | Streptococcus agalactiae (Group B Streptococcus, GBS) is an invasive pathogen that causes sepsis and meningitis among infants, elderly adults, and immunosuppressed patients. Generally, GBS is susceptible to penicillin; however, GBS with reduced penicillin susceptibility (PRGBS) has been reported. PRGBS are commonly isolated from respiratory specimens, but clinical features of patients with PRGBS remain unclear. In this case-control study, clinical features of patients with PRGBS and bacterial characteristics of these isolates from respiratory specimens were investigated. Patients with GBS at the University of the Ryukyus Hospital between January 2017 and June 2018 were retrospectively investigated. GBS were further classified into penicillin-susceptible GBS (PSGBS) and PRGBS using a drug susceptibility test. Moreover, serotypes, genotypes, and drug resistance genes of PRGBS isolates were determined. In total, 362 GBS were isolated, of which 46 were collected from respiratory specimens, which had the highest rate of PRGBS (24%). Compared to patients with PSGBS, those with PRGBS were more likely to have neuromuscular disease, poor performance status, risk of multidrug-resistant pathogen infection, prior pneumonia history within 1 year, and prior penicillin use within 1 year. Among eight PRGBS isolates, multilocus sequence typing revealed that five isolates were sequence type (ST) 358, two were ST3 and ST10, respectively, and one isolate was ST1404. All PRGBS isolates belonged to the ST1/ST19/ST10 group. This study reveals clinical characteristics of patients with PRGBS from respiratory specimens. Because invasive GBS infection cases are increasing, especially in the elderly, more attention should be paid to this infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink