Mechanism of the aspirin-induced rise in blood alcohol levels
| Autor: | R. Sharma, R T Gentry, I Amir, Risto O. Roine, Enrique Baraona, Charles S. Lieber, Z. W. Chayes |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Administration Oral Alcohol General Biochemistry Genetics and Molecular Biology First pass effect chemistry.chemical_compound Sex Factors Internal medicine medicine Humans General Pharmacology Toxicology and Pharmaceutics Ethanol metabolism Infusions Intravenous Alcohol dehydrogenase Volume of distribution Aspirin Ethanol biology Gastric emptying Anti-Inflammatory Agents Non-Steroidal General Medicine Endocrinology Breath Tests Gastric Emptying Liver chemistry Anesthesia biology.protein Female medicine.drug |
| Zdroj: | Life Sciences. 65:2505-2512 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(99)00517-2 |
| Popis: | Aspirin increases blood alcohol levels after post-prandial alcohol consumption in men. This was attributed to a decrease in first pass metabolism secondary to inhibition of gastric alcohol dehydrogenase. Since accelerated gastric emptying, decreased volume of distribution or delayed elimination could also result in higher blood alcohol levels, we investigated the effect of aspirin (1 g taken with a meal) on these parameters. Aspirin did not change the volume of ethanol distribution or the rate of its elimination. Moreover, it did not have a significant effect on gastric emptying. The half-time of 99Tc-DTPA loss was 65.5+/-5.4 minutes without and 71.3+/-6.5, with aspirin. Despite a trend for slower gastric emptying with aspirin, the alcohol bioavailability increased and was associated with a 39% decrease in the first pass metabolism of alcohol (from 106+/-4 to 65+/-19 mg/kg, p |
| Databáze: | OpenAIRE |
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