Liver cirrhosis but not alcohol abuse is associated with impaired outcome in trauma patients – A retrospective, multicentre study
| Autor: | Ingo Marzi, Sebastian Wutzler, Rolf Lefering, H. Wyen, Christoph Nau, Hagen Dörr, H. Laurer, Mark Lehnert |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Multiple Organ Failure Population Alcohol abuse Poison control Injury Severity Score Trauma Centers Risk Factors Germany Internal medicine Odds Ratio medicine Humans education Survival rate Aged Retrospective Studies General Environmental Science Analysis of Variance education.field_of_study Multiple Trauma Platelet Count business.industry Retrospective cohort study Middle Aged medicine.disease Surgery Survival Rate Alcoholism Prothrombin Time Wounds and Injuries General Earth and Planetary Sciences Female business Trauma surgery |
| Zdroj: | Injury. 44:661-666 |
| ISSN: | 0020-1383 |
| Popis: | Introduction Liver cirrhosis has been shown to be associated with impaired outcome in patients who underwent elective surgery. We therefore investigated the impact of alcohol abuse and subsequent liver cirrhosis on outcome in multiple trauma patients. Materials and methods Using the multi-centre population-based Trauma Registry of the German Society for Trauma Surgery, we retrospectively compared outcome in patients (ISS ≥ 9, ≥18) with pre-existing alcohol abuse and liver cirrhosis with healthy trauma victims in univariate and matched-pair analysis. Means were compared using Student's t-test and analysis of variance (ANOVA) and categorical variables using χ2 (p Results Overall 13,527 patients met the inclusion criteria and were, thus, analyzed. 713 (5.3%) patients had a documented alcohol abuse and 91 (0.7%) suffered from liver cirrhosis. Patients abusing alcohol and suffering from cirrhosis differed from controls regarding injury pattern, age and outcome. More specific, liver cirrhotic patients showed significantly higher in-hospital mortality than predicted (35% vs. predicted 19%) and increased single- and multi-organ failure rates. While alcohol abuse increased organ failure rates as well this did not affect in-hospital mortality. Conclusions Patients suffering from liver cirrhosis presented impaired outcome after multiple injuries. Pre-existing condition such as cirrhosis should be implemented in trauma scores to assess the individual mortality risk profile. |
| Databáze: | OpenAIRE |
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