Endothelial biomarkers in the light of new sepsis definition
| Autor: | Dajana Lendak, Dunja Mihajlovic, Biljana Draskovic, Aleksandra Novakov Mikic, Gorana Mitic, Snezana Brkic |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Endothelium Clinical Biochemistry 030204 cardiovascular system & hematology Thrombomodulin Logistic regression Gastroenterology Procalcitonin Sepsis 03 medical and health sciences 0302 clinical medicine Internal medicine Drug Discovery medicine Humans Aged business.industry Septic shock Biochemistry (medical) Middle Aged medicine.disease Systemic inflammatory response syndrome medicine.anatomical_structure ROC Curve 030220 oncology & carcinogenesis Shock (circulatory) Female medicine.symptom business Biomarkers |
| Zdroj: | Biomarkers in Medicine. 13:341-351 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm-2018-0282 |
| Popis: | The aim of our study was to compare usefulness of endothelial biomarkers for severity and outcome prediction in patients with positive Sepsis-3 criteria with traditionally used biomarkers. A total of 150 patients were included in our study. Patients were divided into two groups: patients with sepsis and those with infectious systemic inflammatory response syndrome. Development of septic shock and 28-day mortality were assessed. Endocan and thrombomodulin showed better discriminative power than procalcitonin for the presence of sepsis. Endocan showed good discriminative power for septic shock prediction. Addition of endocan significantly contributed to sequential (sepsis-related) organ failure assessment score in logistic regression model. Conclusion: Endothelial biomarkers have a good diagnostic potential for sepsis. Endocan is useful as a predictor of the severity and fatality of sepsis. |
| Databáze: | OpenAIRE |
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