Studies on protein binding of antibiotics II. Effect of apalcillin on protein binding and pharmacokinetics of cefoperazone and cefazolin
| Autor: | Isamu Saikawa, Kihachiro Shimizu, Rieko Kitayama, Watanabe Yasuo, Yasuda Takashi, Toshio Hayashi |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Cefazolin Serum albumin Cefoperazone Pharmacology Binding Competitive Pharmacokinetics In vivo Drug Discovery medicine Animals Humans Drug Interactions Naphthyridines Apalcillin Serum Albumin biology Chemistry Blood Proteins Human serum albumin Blood proteins Cephalosporins biology.protein Ampicillin Rabbits Protein Binding medicine.drug |
| Zdroj: | The Journal of Antibiotics. 34:753-757 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.34.753 |
| Popis: | The drug-protein interactions between cefoperazone (CPZ) and apalcillin (APPC), and between cefazolin (CEZ) and APPC were investigated in in vitro and in vivo experiments. Through the binding rates of CPZ or CEZ to rabbit serum and human serum albumin subsided remarkably with increased drug concentrations, APPC was not greatly affected, even at high concentrations. It appeared that APPC had a higher binding capacity to protein than CPZ or CEZ. From the results of competitive study, it became clear that APPC partially shared the binding sites on protein with CPZ or CEZ. The CPZ or CEZ serum levels in rabbits administered together with APPC were not different from those for the single administration, but APPC levels for the simultaneous administration were slightly lower. |
| Databáze: | OpenAIRE |
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