High Jagged1 expression is associated with poor outcome in primary glioblastoma
| Autor: | Bi-juan Chen, Yupeng Chen, Xian-xin Qiu, Zhi-xiong Lin, Na You, Xingfu Wang, Chen-hong Wang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Pathology Adolescent Brain tumor Notch signaling pathway Kaplan-Meier Estimate Young Adult Internal medicine Biomarkers Tumor medicine Humans Serrate-Jagged Proteins Young adult Aged Proportional Hazards Models Retrospective Studies Univariate analysis Hematology Brain Neoplasms Proportional hazards model business.industry Calcium-Binding Proteins Membrane Proteins Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Intercellular Signaling Peptides and Proteins Female Glioblastoma business Jagged-1 Protein |
| Zdroj: | Medical Oncology. 32 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-014-0341-9 |
| Popis: | Glioblastoma is a highly aggressive brain tumor. Aberrant Notch pathway has been implicated in the formation and progression of glioblastoma. The present study attempted to investigate the expression of Notch ligand Jagged1 and its association with patient outcome in primary glioblastoma. Tumor tissues from 82 patients with primary glioblastoma were analyzed using immunohistochemistry for Jagged1 expression. Relationships between Jagged1 expression and clinical features (age, gender, KPS, symptom duration, extent of resection and Ki67 index) were evaluated. The prognostic value of Jagged1 was assessed using the Kaplan–Meier survival estimates and the Cox proportional hazard models. Immunohistochemistry results showed markedly increased Jagged1 expression in glioblastoma tissues compared to adjacent non-neoplastic brain tissues. Univariate analysis documented that high Jagged1 expression in tumor cells (TC) and endothelial cells (EC) were both statistically associated with reduced time to progression (TTP) (P |
| Databáze: | OpenAIRE |
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