Structural Insights into PROTAC-Mediated Degradation of Bcl-xL

Autor:	Dongming Qian, Christopher J. Tame, Agnieszka Konopacka, Han Dai, Ian Churcher, Chun-wa Chung, John D. Harling, Esther Fernández, Gillian F. Watt, Markus A. Queisser, Christopher P. Tinworth, Andrew B. Benowitz, Jane Denyer, Jenni Cryan, Fan Jiang
Rok vydání:	2020
Předmět:	0301 basic medicine bcl-X Protein Bcl-xL Plasma protein binding Crystallography X-Ray 01 natural sciences Biochemistry 03 medical and health sciences Cell Line Tumor Humans Benzothiazoles biology 010405 organic chemistry Chemistry General Medicine Isoquinolines 0104 chemical sciences Cell biology 030104 developmental biology Cell culture Von Hippel-Lindau Tumor Suppressor Protein Cancer cell Proteolysis biology.protein Molecular Medicine Oligopeptides Protein Binding
Zdroj:	ACS chemical biology. 15(9)
ISSN:	1554-8937
Popis:	The Bcl-2 family of proteins, such as Bcl-xL and Bcl-2, play key roles in cancer cell survival. Structural studies of Bcl-xL formed the foundation for the development of the first Bcl-2 family inhibitors and FDA approved drugs. Recently
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9fcaed9e9c6a30480d548bb31683e0 https://pubmed.ncbi.nlm.nih.gov/32697072 Zobrazit plný text záznamu