Post-transplantation erythrocytosis in kidney transplant recipients-A retrospective cohort study
Autor: | Oranit Itzhaki, Liron Hofstetter, Ruth Rahamimov, Amir Schechter, Benaya Rozen-Zvi, Anat Gafter-Gvili, Pia Raanani |
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Rok vydání: | 2021 |
Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Multivariate analysis Renal function Polycythemia Kidney Kidney transplant Internal medicine Polycystic kidney disease Medicine Humans Kidney transplantation Retrospective Studies business.industry Proportional hazards model Retrospective cohort study Hematology General Medicine Middle Aged medicine.disease Thrombosis Kidney Transplantation Treatment Outcome Female business Glomerular Filtration Rate |
Zdroj: | European journal of haematologyREFERENCES. 107(6) |
ISSN: | 1600-0609 2005-2014 |
Popis: | OBJECTIVES To characterize risk factors for the development of post-transplant erythrocytosis (PTE), and its long-term effect on mortality, graft failure, and thrombosis. METHODS Retrospective study including all kidney transplant recipients in Rabin Medical Center (RMC) during the years 2005-2014. The primary outcome was a composite outcome of all-cause mortality or graft failure at the end of follow-up. Secondary outcomes included death censored graft loss, venous thromboembolism, major adverse cardiovascular events, and mortality. A matched control group was also evaluated. Univariate and multivariate time-varying Cox model analyses were conducted for outcome evaluation. RESULTS A total of 1304 patients were included, 169 of whom were diagnosed with PTE (12.9%). PTE was associated with male gender, higher glomerular filtration rate (GFR), and polycystic kidney disease. PTE was found to be associated with a reduced risk of the primary outcome (HR 0.355, CI 95% 0.151-0.89, P = .027) in a univariate time-varying Cox analysis, but was not associated with the composite outcome in a multivariate analysis. There was no difference in the primary outcome when the PTE group was compared with the matched control. CONCLUSION PTE was not found to be associated with long-term outcomes of graft failure and poor survival. |
Databáze: | OpenAIRE |
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