Malignant central nervous system tumors among adolescents and young adults (15-39 years old) in 14 Southern-Eastern European registries and the US Surveillance, Epidemiology, and End Results program: Mortality and survival patterns
| Autor: | George A. Alexiou, Paraskevi Papathoma, Panagiotis G. Papanikolaou, Luís Antunes, Joana Bastos, Marios Themistocleous, Spyridon Tzanis, Sultan Eser, Maria Kantzanou, Anna Zborovskaya, Margareta Florea, Domenic Agius, Maria Tolia, Anton Ryzhov, Snezana Zivkovic-Perisic, Anna Demetriou, Tina Žagar, Apostolos Pourtsidis, Daniela Coza, Nick Dessypris, Eleni Petridou, Panagiotis Nomikos, Mario Šekerija, Łukasz Taraszkiewicz, Rajko M. Strahinja, Marios K. Georgakis |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Pediatrics medicine.medical_specialty Adolescent Population Central Nervous System Neoplasms 03 medical and health sciences Young Adult 0302 clinical medicine Epidemiology adolescents and young adults brain tumors central nervous system tumors epidemiology mortality outcome survival medicine Surveillance Epidemiology and End Results Humans Europe Eastern Registries Young adult education Survival rate education.field_of_study Proportional hazards model business.industry Mortality rate United States Eastern european Europe Survival Rate 030104 developmental biology Oncology 030220 oncology & carcinogenesis Female business SEER Program |
| Popis: | BACKGROUND Unique features and worse outcomes have been reported for cancers among adolescents and young adults (AYAs; 15-39 years old). The aim of this study was to explore the mortality and survival patterns of malignant central nervous system (CNS) tumors among AYAs in Southern-Eastern Europe (SEE) in comparison with the US Surveillance, Epidemiology, and End Results (SEER) program. METHODS Malignant CNS tumors diagnosed in AYAs during the period spanning 1990-2014 were retrieved from 14 population-based cancer registries in the SEE region (n = 11,438). Age-adjusted mortality rates were calculated and survival patterns were evaluated via Kaplan-Meier curves and Cox regression analyses, and they were compared with respective 1990-2012 figures from SEER (n = 13,573). RESULTS Mortality rates in SEE (range, 11.9-18.5 deaths per million) were higher overall than the SEER rate (9.4 deaths per million), with decreasing trends in both regions. Survival rates increased during a comparable period (2001-2009) in SEE and SEER. The 5-year survival rate was considerably lower in the SEE registries (46%) versus SEER (67%), mainly because of the extremely low rates in Ukraine; this finding was consistent across age groups and diagnostic subtypes. The highest 5-year survival rates were recorded for ependymomas (76% in SEE and 92% in SEER), and the worst were recorded for glioblastomas and anaplastic astrocytomas (28% in SEE and 37% in SEER). Advancing age, male sex, and rural residency at diagnosis adversely affected outcomes in both regions. CONCLUSIONS Despite definite survival gains over the last years, the considerable outcome disparities between the less affluent SEE region and the United States for AYAs with malignant CNS tumors point to health care delivery inequalities. No considerable prognostic deficits for CNS tumors are evident for AYAs versus children. Cancer 2017. © 2017 American Cancer Society. |
| Databáze: | OpenAIRE |
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