Poor sensitivity of fecal gluten immunogenic peptides and serum antibodies to detect duodenal mucosal damage in celiac disease monitoring
| Autor: | Teresa Angueira, Ángel Arias, Emilia Tébar-Romero, Mirella Jiménez, María Ángeles Tejero-Bustos, Alfredo J. Lucendo, Pedro Majano, Laura Arias-González, María José Casanova, Luis Alberto Mate, Javier P. Gisbert, Emilio J Laserna-Mendieta, Cecilio Santander, María Jesús Carrillo-Ramos, Carlos Humberto Gordillo-Vélez |
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| Přispěvatelé: | UAM. Departamento de Anatomía Patológica, UAM. Departamento de Medicina |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Tissue transglutaminase Gluten immunogenic peptides Gastroenterology Diagnostic accuracy Feces 0302 clinical medicine Surveys and Questionnaires Gluten-free diet monitoring Celiac disease Prospective Studies 030212 general & internal medicine Intestinal Mucosa Prospective cohort study chemistry.chemical_classification Nutrition and Dietetics biology Disease monitoring Female 030211 gastroenterology & hepatology Antibody lcsh:Nutrition. Foods and food supply Adult medicine.medical_specialty Adolescent Glutens Duodenum Medicina lcsh:TX341-641 Article Antibodies 03 medical and health sciences Internal medicine medicine Humans Reference standards Monitoring Physiologic business.industry nutritional and metabolic diseases Anti-tissue transglutaminase antibodies Gold standard (test) Gluten digestive system diseases chemistry biology.protein Peptides business Marsh–Oberhüber type Food Science |
| Zdroj: | Nutrients Volume 13 Issue 1 Nutrients, Vol 13, Iss 98, p 98 (2021) Biblos-e Archivo. Repositorio Institucional de la UAM instname |
| Popis: | A lifelong gluten-free diet (GFD) is the only current treatment for celiac disease (CD), but strict compliance is complicated. Duodenal biopsies are the &ldquo gold standard&rdquo method for diagnosing CD, but they are not generally recommended for disease monitoring. We evaluated the sensitivity and specificity of fecal gluten immunogenic peptides (GIPs) to detect duodenal lesions in CD patients on a GFD and compared them with serum anti-tissue transglutaminase (tTG) IgA antibodies. A prospective study was conducted at two tertiary centers in Spain on a consecutive series of adolescents and adults with CD who maintained a long-lasting GFD. Adherence to a GFD and health-related quality of life were scored with validated questionnaires. Mucosal damage graded according to the Marsh&ndash Oberhü ber classification (Marsh 1/2/3) was used as the reference standard. Of the 97 patients included, 27 presented duodenal mucosal damage and 70 had normal biopsies (Marsh 0). The sensitivity (33%) and specificity (81%) of GIPs were similar to those provided by the two assays used to measure anti-tTG antibodies. Scores in questionnaires showed no association with GIP, but an association between GIPs and patients&rsquo self-reported gluten consumption was found (p = 0.003). GIP displayed low sensitivity but acceptable specificity for the detection of mucosal damage in CD. |
| Databáze: | OpenAIRE |
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