Antidrug Resistance in the Indian Ambient Waters of Ahmedabad during the COVID-19 Pandemic
| Autor: | Christian Sonne, Bhagwana Ram, Nirav P. Raval, Vaibhav Srivastava, Abhay Kumar, Tushara Chaminda, Manish Kumar, Kiran Dhangar, Alok Kumar Thakur, Keisuke Kuroda, Jörg Rinklebe, Damià Barceló, Pradeep Kumar Sharma |
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| Přispěvatelé: | Indian Institute of Technology Gandhinagar, United Nations Children's Fund, UK-India Education and Research Initiative, Kumar, Manish [0000-0002-3351-7298], Kumar, Manish |
| Rok vydání: | 2021 |
| Předmět: |
Environmental Engineering
Coronavirus disease 2019 (COVID-19) Health Toxicology and Mutagenesis Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 0211 other engineering and technologies 02 engineering and technology Ambient water Wastewater 010501 environmental sciences 01 natural sciences Article Toxicology Pandemic Escherichia coli Humans Environmental Chemistry Medicine Faecal pollution Pandemics Waste Management and Disposal 0105 earth and related environmental sciences 021110 strategic defence & security studies business.industry SARS-CoV-2 Incidence (epidemiology) COVID-19 Antimicrobial Pollution Antidrug resistance business Wastewater based epidemiology |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Kumar, M, Dhangar, K, Thakur, A K, Ram, B, Chaminda, T, Sharma, P, Kumar, A, Raval, N, Srivastava, V, Rinklebe, J, Kuroda, K, Sonne, C & Barcelo, D 2021, ' Antidrug resistance in the Indian ambient waters of Ahmedabad during the COVID-19 pandemic ', Journal of Hazardous Materials, vol. 416, 126125 . https://doi.org/10.1016/j.jhazmat.2021.126125 Journal of Hazardous Materials Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) |
| DOI: | 10.1016/j.jhazmat.2021.126125 |
| Popis: | The ongoing COVID-19 pandemic increases the consumption of antimicrobial substances (ABS) due to the unavailability of approved vaccine(s). To assess the effect of imprudent consumption of ABS during the COVID-19 pandemic, we compare the 2020 prevalence of antidrug resistance (ADR) of Escherichia coli (E. coli) with a similar survey carried out in 2018 in Ahmedabad, India using SARS-CoV-2 gene detection as a marker of ABS usage. We found a significant ADR increase for in 2020 compared to 2018 in ambient water bodies, harbouring a higher incidence of ADR E.Coli towards non-fluoroquinolone drugs. Effective SARS-CoV-2 genome copies were found to be associated with the ADR prevalence. The prevalence of ADR depends on the efficiency of WWTPs (Wastewater Treatment Plants) and the catchment area in its vicinity. In year 2018 study, prevalence of ADR was discretely distributed, and the maximum ADR prevalence recorded was ~60%; against the current homogenous ADR increase, and up to 85% of maximum ADR among the incubated E.coli isolated from the river (Sabarmati) and lake (Chandola and Kankaria) samples. Furthermore, wastewater treatment plants showed less increase in comparison to the ambient waters, which eventually imply that although SARS-CoV-2 genes and faecal pollution may be diluted in the ambient waters, as indicated by low Ct-value and E.coli count, the danger of related aftermath like ADR increase cannot be nullified. Also, Non-fluoroquinolone drugs exhibited overall more resistance than the quinolone drugs. Overall, this is probably the first ever study that traces the COVID-19 pandemic imprints on the prevalence of antidrug resistance (ADR) through wastewater surveillance and hints at monitoring escalation of other environmental health parameters. This study will make public and policyholders concerned about the optimum use of antibiotics during any kind of treatment. This work is funded by Kiran C Patel Centre for Sustainable Development at IIT Gandhinagar, UNICEF, Gujarat and UKIERI. We also acknowledge the help received from Dr. Vaibhav Srivastava, Dr. Arbind K Patel, and other GBRC staffs who contributed towards sample and data analyses. |
| Databáze: | OpenAIRE |
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