ICAM-1, E-selectin, and TNF alpha expression in labial salivary glands of patients with rheumatoid vasculitis
| Autor: | Marie Vandecandelaere, Marie Christine Copin, René Marc Flipo, Anne Janin, Thierry Cardon, Bernard Duquesnoy |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
musculoskeletal diseases
Male Vasculitis Pathology medicine.medical_specialty Immunology General Biochemistry Genetics and Molecular Biology Salivary Glands Extended Reports Arthritis Rheumatoid Rheumatology stomatognathic system Rheumatic Diseases Labial glands medicine Immunology and Allergy Humans Prospective Studies skin and connective tissue diseases Salivary gland business.industry Tumor Necrosis Factor-alpha Middle Aged medicine.disease Connective tissue disease Immunohistochemistry Lip stomatognathic diseases Purpura medicine.anatomical_structure Sjogren's Syndrome Rheumatoid arthritis Rheumatoid vasculitis Female medicine.symptom business Cell Adhesion Molecules Cerebral vasculitis |
| Zdroj: | Annals of the rheumatic diseases. 56(1) |
| ISSN: | 0003-4967 |
| Popis: | OBJECTIVE—To assess the expression of ICAM1, VCAM1, E-selectin, CD44, and TNF α in labial salivary glands of patients with rheumatoid vasculitis. METHODS—Labial salivary glands from six patients with rheumatoid vasculitis before and after treatment, six aged matched rheumatoid arthritis patients without clinical evidence of rheumatoid vasculitis, 10 patients with primary Sjogren syndrome, 10 patients with rheumatoid arthritis and proven secondary Sjogren syndrome, and six controls were tested with specific antibodies. RESULTS—ICAM1, E-selectin, and TNF α were significantly expressed in endothelial cells and perivascular cellular infiltrate only in rheumatoid vasculitis before treatment. CONCLUSIONS—The expression of ICAM1, E-selectin, and TNF α allows an assessment of the activity of the vasculitic process in rheumatoid vasculitis. Labial salivary gland biopsy findings in patients with rheumatoid arthritis and visceral vasculitis without purpura or neuropathy (that is, mesenteric, coronary, or cerebral vasculitis) would be of interest and are examples where labial salivary gland tissue is more accessible than the affected tissue. |
| Databáze: | OpenAIRE |
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