The Use of Transdermal Buprenorphine in Complex Regional Pain Syndrome: A Report of Two Cases
| Autor: | Sarah Onofrio, Christine M. Vartan, Sandra DiScala, John Melendez-Benabe, Ramon Cuevas-Trisan, Mitchell Nazario |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Agonist medicine.drug_class medicine.medical_treatment Transdermal Patch δ-opioid receptor 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology medicine Humans Pharmacology (medical) Receptor Aged Pain Measurement Transdermal business.industry medicine.disease Rash Buprenorphine Analgesics Opioid Treatment Outcome Anesthesiology and Pain Medicine Complex regional pain syndrome Anesthesia medicine.symptom business Complex Regional Pain Syndromes 030217 neurology & neurosurgery Topical steroid medicine.drug |
| Zdroj: | Journal of Pain & Palliative Care Pharmacotherapy. 30:124-127 |
| ISSN: | 1536-0539 1536-0288 |
| DOI: | 10.3109/15360288.2016.1173756 |
| Popis: | Management of complex regional pain syndrome (CRPS) can be challenging. Various pharmacological approaches have produced mixed results. Buprenorphine activates mu-opioid receptors and antagonizes kappa and delta receptors, acts at N-methyl-d-aspartate (NMDA) receptor, and is an orphan-related ligand-1 receptor agonist. It is available in transdermal patches that last for up to 7 days. This report describes two patients with refractory CRPS who were treated with transdermal buprenorphine. The patients experienced approximately 50% reduction in pain intensity scores. Application site rash that occurred was managed with topical steroid spray used before applying the patch. |
| Databáze: | OpenAIRE |
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