Effects of birth on energy metabolism in the rat kidney
| Autor: | Jean Bastin, Evelyne Delaval, M. Razanoelina, Jean-Pierre Geloso, Jeanne Bismuth, Fatima Djouadi, Nicole Freund |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Phosphocreatine Oxidative phosphorylation Mitochondrion Biology Creatine Kidney Biochemistry Fumarate Hydratase chemistry.chemical_compound Adenosine Triphosphate Oxygen Consumption Internal medicine medicine Animals Molecular Biology Days post coitum Palmitoylcarnitine 3-Hydroxyacyl CoA Dehydrogenases Rats Inbred Strains Cell Biology Mitochondria Rats medicine.anatomical_structure Endocrinology chemistry Animals Newborn Anaerobic glycolysis Fumarase Energy Metabolism Research Article |
| Zdroj: | The Biochemical journal. 252(2) |
| ISSN: | 0264-6021 |
| Popis: | The oxygen-consumption rates and the activities of fumarase and beta-hydroxyacyl-CoA dehydrogenase were compared in mitochondria isolated from fetal- and neonatal-rat kidney. Whole-organ ATP, phosphocreatine and creatine contents were determined in parallel. Kidney mitochondrial respiratory rates in the presence of succinate, glutamate/malate and palmitoyl-L-carnitine increased between 21 days post coitum and 1 day post partum, together with activities of oxidative enzymes. However, this postnatal maturation of oxidative metabolism was not yet initiated in mitochondria isolated from kidney 1 h post partum. An increase in ATP and phosphocreatine was observed immediately after delivery; newborn-rat kidney ATP content then remained high, whereas phosphocreatine reserves decreased considerably between 6 h and 1 day post partum. It is concluded that the increase in high-energy phosphate compounds observed at birth is not initially related to an activation of oxidative phosphorylation, and probably involves a transient stimulation of anaerobic glycolysis, while a progressive mitochondrial maturation takes place in the rat kidney during the first day of newborn life. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|