Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice
| Autor: | Thuliermes Lopes Pamplona, Francisco Vagnaldo Fechine, Ricardo Reges Maia de Oliveira, Marcos Fiuza de Carvalho, Márcio Alencar Barreira, Lúcio Flávio Gonzaga-Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
RD1-811 media_common.quotation_subject Muscle Relaxation Urinary Bladder Urology Nitric Oxide Urination Mice Medicine media_common Urinary bladder Óxido Nítrico medicine.diagnostic_test business.industry Urinary Bladder Overactive Relaxamento Muscular Cystometry Bexiga Urinária medicine.disease Tadalafil Muscle relaxation medicine.anatomical_structure Overactive bladder Surgery Analysis of variance business Co administration medicine.drug |
| Zdroj: | Acta Cirúrgica Brasileira v.34 n.2 2019 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Vol 34, Iss 2 (2019) Acta Cirurgica Brasileira, Volume: 34, Issue: 2, Article number: e201900205, Published: 28 FEB 2019 Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| Popis: | Purpose: To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. Methods: Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1: Control; G2: L-NAME; G3: L-NAME + TDF; G4: L-NAME + BRL 37344; G5: L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystometry to evaluate non-voiding contractions (NVC), threshold pressure (TP), baseline pressure (BP), frequency of micturition (FM) and threshold volume (TV). Differences between the groups were analyzed with ANOVA followed by the Tukey test. Results: NVC increased in G2 (4.33±2.58) in relation to G1 (1.50±0.55). NVC decreased in G3 (2.00±1.10), G4 (1.50±1.52) and G5 (2.00±1.26) compared to G2 (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|