Emergence of acyclovir-resistant varicella zoster virus in an AIDS patient on prolonged acyclovir therapy
| Autor: | Alan M. Solinger, William G. Hoppenjans, Karen K. Biron, Calvin C. Linnemann |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Acquired Immunodeficiency Syndrome Herpesvirus 3 Human integumentary system business.industry viruses Immunology Varicella zoster virus Acyclovir virus diseases Drug Resistance Microbial medicine.disease medicine.disease_cause Herpes Zoster Thymidine Kinase Virology Infectious Diseases Acquired immunodeficiency syndrome (AIDS) medicine Humans Immunology and Allergy Female business Skin lesion |
| Zdroj: | AIDS. 4:577-580 |
| ISSN: | 0269-9370 |
| Popis: | We demonstrate for the first time the appearance of acyclovir resistance in serial varicella zoster isolates from a patient treated with acyclovir. We recovered varicella zoster virus three times over a period of 5 months from the skin lesions of this patient with AIDS who was treated with three courses of intravenous acyclovir and prolonged low-dose oral acyclovir. The isolate recovered from a typical zoster lesion before acyclovir, and one obtained from a hyperkeratotic lesion 2 months later, after intravenous and oral acyclovir, were sensitive to acyclovir and produced normal amounts of thymidine kinase. In contrast, virus recovered from lesions 5 months after the onset, when the patient had received repeated courses of acyclovir, was acyclovir-resistant and thymidine-kinase-deficient. Resistance to acyclovir was associated with persistence of lesions which failed to improve with intravenous acyclovir, but was not associated with new lesion formation. |
| Databáze: | OpenAIRE |
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