Pharmacokinetic analysis of blood distribution of intravenously administered 153Gd-labeled Gd(DTPA)2− and 99MTc(DTPA) in rats
| Autor: | D.G. Covell, S. Nair, Paul W. Wedeking, Stephen Eaton, Michael F. Tweedle, W.C. Eckelman |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Gadolinium DTPA
Male Time Factors Gadolinium Biomedical Engineering Biophysics Contrast Media chemistry.chemical_element Technetium Models Biological Isotopes of technetium chemistry.chemical_compound Nuclear magnetic resonance Pharmacokinetics Technetium-99 Blood plasma Confidence Intervals Organometallic Compounds Animals Tissue Distribution Radiology Nuclear Medicine and imaging Radioisotopes Blood Volume Pentetic acid Radiochemistry Rats Inbred Strains Pentetic Acid Rats chemistry Injections Intravenous Technetium Tc 99m Pentetate Technetium-99m |
| Zdroj: | Magnetic Resonance Imaging. 8:567-575 |
| ISSN: | 0730-725X |
| DOI: | 10.1016/0730-725x(90)90133-m |
| Popis: | Rat plasma distribution data obtained following IV administration of 99mTc(DTPA) alone or after co-administration of 99mTc(DTPA) and 153Gd-labeled Gd(DTPA)2- at 0.001, 0.1, and 1.0 mmol Gd/kg were evaluated using compartmental modeling techniques. A three-compartment open model was found to fit the data significantly better (P less than 0.01) than a two- or four-compartment open model. This model incorporates and links the plasma and urine data and includes a delay to account for the transit time through the kidneys/ureters. The two nonplasma compartments of the model were assumed to be related to rapidly and slowly equilibrating tissues. Tc(DTPA) and Gd(DTPA)2- had nearly identical pharmacokinetic profiles in plasma and the rate constants were essentially the same. No significant dose dependent pharmacokinetic differences were found for the range of Gd(DTPA)2- doses tested. Simulations of the proposed three-compartment model were used to generate concentration-time curves for each of the three compartments. |
| Databáze: | OpenAIRE |
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