Early human herpes virus type 6 reactivation in umbilical cord blood allogeneic stem cell transplantation

Autor:	Sebastian Mayer, Usama Gergis, Tsiporah B. Shore, Koen van Besien, Xi Kathy Zhou, Frank Cirrone, Hanhan Wang, Cindy Ippoliti
Rok vydání:	2016
Předmět:	Adult Male Cancer Research Adolescent Herpesvirus 6 Human Graft vs Host Disease Roseolovirus Infections Cord Blood Stem Cell Transplantation Umbilical cord Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Transplantation Homologous Platelet Young adult Survival analysis Aged Retrospective Studies business.industry Incidence Hematology Middle Aged medicine.disease Survival Analysis Blood Cell Count Transplantation Graft-versus-host disease medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Immunology Female Virus Activation Stem cell business 030215 immunology
Zdroj:	Leukemia & Lymphoma. 57:2555-2559
ISSN:	1029-2403 1042-8194
DOI:	10.3109/10428194.2016.1157873
Popis:	Human herpes virus type 6 can reactivate in patients after allogeneic stem cell transplantation and has been associated with serious sequelae such as delayed engraftment and an increased risk of developing acute graft-versus-host disease (GVHD). This study investigated human herpes virus type 6 (HHV-6) reactivation within 60 days of transplantation in stem cell transplants utilizing single umbilical cord blood, double umbilical cord blood, or umbilical cord blood plus haploidentical stem cells. Of 92 patients, 60 (65%) had HHV-6 reactivation. Reactivation was not significantly influenced by any patient characteristics, disease characteristics, or by stem cell source (umbilical cord blood only versus haploidentical plus umbilical cord blood). We did not observe any impact of HHV-6 reactivation on neutrophil or platelet count recovery or on relapse-free survival. HHV-6 reactivation was associated with subsequent development of prerelapse acute GVHD (HR = 3.00; 95% CI, 1.4 to 6.4; p = 0.004).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db90632cfd107b4de968929706c78d85 https://doi.org/10.3109/10428194.2016.1157873 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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