Comparison of cardiovascular effects of mu- and delta-opioid receptor antagonists in dogs with congestive heart failure
| Autor: | Chang-seng Liang, P. D. Woolf, Michihiro Kashiki, N. Imai |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Physiology medicine.drug_class Narcotic Antagonists Receptors Opioid mu Hemodynamics (+)-Naloxone Cardiovascular System Dogs Opioid receptor Physiology (medical) Internal medicine Receptors Opioid delta medicine Animals Endogenous opioid Heart Failure business.industry Naloxone medicine.disease Blood pressure Endocrinology Opioid Regional Blood Flow Heart failure Blood Circulation Ventricular pressure Ventricular Function Right Cardiology and Cardiovascular Medicine business medicine.drug Enkephalin Leucine |
| Zdroj: | The American journal of physiology. 267(3 Pt 2) |
| ISSN: | 0002-9513 |
| Popis: | We have shown previously that right heart failure (RHF) in dogs is associated with activated endogenous opiate systems, and that administration of the opioid receptor antagonist, naloxone, increases arterial pressure, cardiac contractile function and organ blood flows. To study whether the cardiovascular effects of naloxone are mediated via the mu- or delta-opioid receptors, we administered ICI-154,129, a delta-receptor antagonist, and naloxonazine, a mu-receptor antagonist, to 10 conscious dogs with RHF on 2 separate days. Like naloxone, ICI-154,129 increased mean aortic pressure, cardiac output, peak positive first derivative of left ventricular pressure, and blood flows to the myocardium, kidneys, splanchnic beds, and skeletal muscle. These changes were associated with increases in plasma epinephrine and norepinephrine. In contrast, naloxonazine had no effects on systemic hemodynamics, regional blood flow distribution, and plasma catecholamines in RHF. These findings suggest that the increased endogenous opioids during heart failure act on the delta-opioid receptors to decrease myocardial mechanical performance and alter regional blood flow distribution. Opioid receptor-blocking agents may exert beneficial cardiovascular effects in heart failure. |
| Databáze: | OpenAIRE |
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