Hypericin Site Specific Interactions Within Polynucleotides Used as DNA Model Compounds
| Autor: | L. Chinsky, Pierre-Yves Turpin, Gavin V. Wheeler, Pavol Miskovsky |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Guanine
Polynucleotides Resonance Raman spectroscopy Photochemistry Antiviral Agents chemistry.chemical_compound Polydeoxyribonucleotides Poly dA-dT Structural Biology Molecule Perylene Molecular Biology Anthracenes chemistry.chemical_classification Binding Sites Molecular Structure General Medicine Polymer Resonance (chemistry) Hypericin Poly C chemistry Polynucleotide Poly G Nucleic acid |
| Zdroj: | Journal of Biomolecular Structure and Dynamics. 13:547-552 |
| ISSN: | 1538-0254 0739-1102 |
| DOI: | 10.1080/07391102.1995.10508865 |
| Popis: | Summary Interactions of the antiretroviral hypericin molecule with polynucleotides, i.e. poly(dG-dC), poly(dA-dT), poly(rG) and poly(rC), have been studied in aqueous solutions by resonance Raman spectroscopy, using an UV excitation wavelength which induces a specific resonance enhancement of spectral band intensities corresponding to proper nucleic base modes of vibration. It is shown that : i) hypericin selectively interacts with the N7 sites of purines, ii) the strength of interaction depends on the polymer structure, and : iii) interaction with guanine is stronger than with adenine molecules. |
| Databáze: | OpenAIRE |
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