Gold amides as anticancer drugs: synthesis and activity studies

Autor:	Eva Hoffmann, Christopher W. D. Gallop, Helen Yong, Sonya Newcombe, Mariusz Bobin, Rebecca Gates, Yannick Pace, Mark Roe, Amruta Shrikhande, Shuvashri Chaudhuri, Eddy M. E. Viseux
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Cell Survival RD0651 Antineoplastic Agents Biochemistry RC0254 chemistry.chemical_compound Structure-Activity Relationship Breast cancer cell line Amide Cell Line Tumor Structure–activity relationship Organogold Compounds Humans QD Physical and Theoretical Chemistry Cell Proliferation RM0300 chemistry.chemical_classification RS0400 Dose-Response Relationship Drug Molecular Structure Cell growth Chemistry Organic Chemistry Drugs synthesis Epithelial Cells Combinatorial chemistry Amides Amino acid Drug synthesis Nigericin Gold Drug Screening Assays Antitumor QD0146 RM0671 QD0241
ISSN:	1477-0520
Popis:	Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8bfc3b222bb90744e2ccdd68bacbfe http://sro.sussex.ac.uk/id/eprint/44189/1/c3ob27460h.pdf Zobrazit plný text záznamu