Prevalence and correlates of sleep disturbance in systemic sclerosis--results from the UCLA scleroderma quality of life study
| Autor: | Ron D. Hays, Tracy M. Frech, Philip J. Clements, Paul Maranian, Daniel E. Furst, Dinesh Khanna |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Sleep Wake Disorders medicine.medical_specialty SF-36 Population Comorbidity Severity of Illness Index Age Distribution Rheumatology Quality of life Dyssomnia Sickness Impact Profile Internal medicine Prevalence medicine Chronic fatigue syndrome Humans Pharmacology (medical) Longitudinal Studies Sex Distribution skin and connective tissue diseases education Depression (differential diagnoses) Aged Academic Medical Centers Sleep disorder education.field_of_study Scleroderma Systemic integumentary system business.industry Middle Aged Clinical Science medicine.disease Los Angeles Dyssomnias Quality of Life Physical therapy Regression Analysis Female business |
| Zdroj: | Rheumatology. 50:1280-1287 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/ker020 |
| Popis: | Objective. Rheumatologic disorders are associated with sleep disturbances. This study examines sleep disturbance correlates in patients with SSc. Methods. Participants are 180 SSc patients in an observational study. At baseline, patients completed the Medical Outcomes Study Sleep measure (MOS-Sleep scale). In addition, patients were administered other patient-reported outcome (PRO) measures including the 36-item short form (SF-36), HAQ disability index (HAQ-DI), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue), Center for Epidemiologic Studies Depression (CESD) scale and a University of California at Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract Questionnaire (UCLA SCTC GIT 2.0). Descriptive statistics were assessed for six scales of MOS-Sleep and the 9-item sleep problem index (SLP-9; a composite index). We computed Spearman’s rank-order correlations between the MOS-Sleep scales and the HAQ-DI, FACIT-Fatigue, CESD, SSc-SCTC GIT 2.0 and SF-36 scales. In addition, we developed a regression model to assess predictors of SLP-9 scores. Covariates included demographics, physician variables of disease severity and patient-reported variables of worsening symptoms and the PRO measures. Results. SSc patients reported a mean (S.D.) of 7.1 (1.73) h of sleep a night. Patients reported worse scores on four of six scales (except for snoring and sleep quantity) compared with the US general population (P < 0.001). SLP-9 was correlated with worsening pain and dyspnoea over the past 1 month, reflux scale of the UCLA SCTC GIT 2.0, CESD and FACIT-Fatigue (� 0.260.56). In the stepwise multivariate regression model, the CESD, worsening dyspnoea and reflux scale were significantly associated with SLP-9 index. Conclusion. Sleep disturbances are common in SSc and are associated with worsening dyspnoea, depressed mood and severity of reflux symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|